Robotic tormenter depresses lab rats



Hal Hodson, technology reporter


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(Image: Chris Nash/iamchrisphotography/Getty)



Lab rats have a new companion, but it's not friendly. Researchers at Waseda University in Tokyo, Japan, have developed a robotic rat called WR-3 whose job is to induce stress and depression in lab animals, creating models of psychological conditions on which new drugs can be tested.





Animal are used throughout medicine as models to test treatments for human conditions, including mental disorders like depression. Rats and mice get their sense of smell severed to induce something like depression, or are forced to swim for long periods, for instance. Other methods rely on genetic modification and environmental stress, but none is entirely satisfactory in recreating a human-like version of depression for treatment. Hiroyuki Ishii and his team aim to do better with WR-3.

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(Image: Takanishi Lab/Waseda University) 

The researchers tested WR-3's ability to depress two groups of 12 rats, measured by the somewhat crude assumption that a depressed rat moves around less. Rats in group A were constantly harassed by their robot counterpart, while the other rats were attacked intermittently and automatically by WR-3, whenever they moved. Ishii's team found that the deepest depression was triggered by intermittent attacks on a mature rat that had been constantly harassed in its youth.


The team say they plan to test their new model of depression against more conventional systems, like forced swimming.


The robot has been developed just as new research by Junhee Seok of Stanford University in Palo Alto, California, and colleagues shows that the use of mouse models for human conditions has led researchers trying to find treatments for sepsis, burns and trauma astray at a cost of billions of tax dollars.



Journal reference: Advanced Robotics, DOI: 10.1080/01691864.2013.752319




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Syrian rebels seize military airport






DAMASCUS: Rebels on Tuesday overran a military air base, a watchdog said, a day after seizing control of Syria's largest dam as they pushed an assault on strategic targets in the north of the country.

The military advance came as prospects for a political solution to Syria's civil war faded and as UN Secretary General Ban Ki-moon urged President Bashar al-Assad's regime to accept an offer of dialogue by an opposition leader.

The Syrian Observatory for Human Rights said the rebels captured a military airport in Al-Hajjar in Aleppo province, and in the process seized for the first time a fleet of deployable warplanes including MiG fighter jets.

During their assault on the airport, the rebels killed, injured or imprisoned some 40 troops, the Britain-based watchdog said.

"The remainder of the troops pulled out from the airport, leaving behind several warplanes and large amounts of ammunition," Observatory director Rami Abdel Rahman told AFP.

Rebels also launched offensives on other airports in the region, activists said.

"At dawn Tuesday, several rebel battalions launched simultaneous assaults on Aleppo international airport and Nayrab military airport," the grassroots anti-regime Aleppo Media Centre said via Facebook.

The international airport at Syria's second city has been closed since January 1.

Activists in Aleppo have told AFP that fighters in the north have shifted their focus to the capture of military airports and bases.

"They are important because they are an instant source of ammunition and supplies, and because their capture means putting out of action the warplanes used to bombard us," Aleppo-based activist Abu Hisham said via the Internet.

But while the rebels have notched up victories in northern and eastern Syria they have yet to take a major city in the war-ravaged country, which is largely at a military stalemate almost two years into the revolution.

The capture of Al-Jarrah airport came just over a month after rebels overran Taftanaz airbase, the largest in northern Syria.

Amateur video shot by rebels overrunning Al-Jarrah and distributed via the Internet showed a fleet of warplanes lining the airport's runways.

"Thank God, Ahrar al-Sham (Islamist rebels) have overrun the military airport" at Al-Jarrah, said an unidentified cameraman who shot a video at the site.

"MiG warplanes are now in the hands of Ahrar al-Sham. And here is the ammunition," the cameraman added, filming two Russian-made fighter jets similar to those used by the army since last summer to bombard rebel targets.

The authenticity of the video was impossible to verify.

The battlefield assaults came just hours after the UN's Ban urged Assad's regime to view an offer for talks with Syrian National Coalition chief Moaz al-Khatib as "an opportunity we should not miss -- a chance to switch from a devastating military logic to a promising political approach".

Speaking at the Council on Foreign Relations in New York, Ban described as "courageous" Khatib's offer for talks.

Khatib said in late January he was prepared to hold direct talks with regime representatives without "blood on their hands," on condition the talks focus on replacing Assad.

The Assad regime has said it was open to talks but without conditions attached.

The UN Security Council, currently divided over Syria, "must no longer stand on the sidelines, deadlocked, silently witnessing the slaughter," said Ban.

According to UN figures, more than 60,000 people have been killed in violence across Syria since the eruption of an anti-Assad revolt in March 2011.

As well as lives lost, the raging conflict has caused massive infrastructural and economic damage.

On Tuesday, Syria's state news agency SANA cited electricity minister Imad Khamis as saying widespread blackouts have caused economic losses of around $2.2 billion since March 2011.

Supporters of Assad's regime meanwhile planned a demonstration for next Tuesday in Damascus, under the slogan "resistance against terrorism", using the authorities' term for rebels.

The Observatory said at least 137 people were killed in violence across the country on Monday. Among them were 49 civilians.

- AFP/al



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Apple's Greenlight suit response to come by tomorrow



Apple will soon respond to the lawsuit filed against it last week by David Einhorn's Greenlight Capital.


According to the Wall Street Journal, Apple plans to file its response to Greenlight by tomorrow. Greenlight will then file its reply on Friday. Both sides would like for the hearing to be held early next week.


The Greenlight hedge fund filed a lawsuit against Apple last week saying that the company should distribute high-yield preferred stock to shareholders, allowing the company to both hold a large amount of its cash, but also give its shareholders more of the value of Apple's cash hoard.



Apple's cash reserves now total more than $137 billion. Apple has so far delivered $10 billion of its planned $45 billion to shareholders.


Apple has been making it clear it wants to handle the Greenlight case as much as possible. Just yesterday, Judge Richard Sullivan of the U.S. Court for the Southern District of New York granted Apple's request to fast-track the lawsuit.


That Apple is pushing ahead with the lawsuit isn't all that surprising. The company plans to hold its shareholders' meeting on February 27, and doesn't want the lawsuit to take center stage. Apple has also made clear that it's willing to work with Greenlight to come to an amicable solution.


"Apple's management team and board of directors have been in active discussions about returning additional cash to shareholders," the company said last week. "As part of our review, we will thoroughly evaluate Greenlight Capital's current proposal to issue some form of preferred stock. We welcome Greenlight's views and the views of all of our shareholders."

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Obama Calls N. Korea Nuke Test 'Highly Provocative'













President Obama called North Korea's latest nuclear test "a highly provocative act" that undermines regional stability and threatens international peace.


North Korea announced earlier today that it successfully tested a miniaturized nuclear device underground, according to state media.


Official state media said the test was conducted in a safe manner and is aimed at coping with "outrageous" U.S. hostility that "violently" undermines the North's peaceful, sovereign rights to launch satellites. Unlike previous tests, North Korea used a powerful explosive nuclear bomb that is smaller and lighter, state media reported.


North Korea kept up its belligerent talk today, vowing more provocative actions.


If the U.S. "makes this situation complex in hostility, we will come up with second and third reactions," North Korea said in a statement.


The regime blamed the nuclear test on the United States.


"Originally we didn't have to test the nuclear bomb and we didn't plan to," the statement said. "The major purpose of this test is to show our anger to the hostile actions of the U.S. and show off our will and capability to protect our sovereign right to the end."


The statement lashed out at the U.S.-led sanctions as well as the search of North Korean ships that are suspected of exporting illegal arms.


"We will consider the search of our ships and other sanctions by the international community as an act of war. And it will bring on our relentless retaliatory attack," North Korea said.


Obama also talked tough today.








North Korea Says it Has Conducted a Nuclear Test Watch Video









"The danger posed by North Korea's threatening activities warrants further swift and credible action by the international community. The United States will also continue to take steps necessary to defend ourselves and our allies.


"The United States remains vigilant in the face of North Korean provocations and steadfast in our defense commitments to allies in the region," he added.


The U.N. Security Council will hold an emergency meeting on North Korea's nuclear test later this morning.


China's Ministry of Foreign Affairs released a statement expressing "firm opposition" to the test.


"We strongly urge the DPRK (North Korea) to abide by its denuclearization commitments, and to refrain from further actions that could lead to a deterioration of the situation," the statement read. "Safeguarding Korean Peninsula and East Asian peace and stability serves the shared interests of all parties."


China, North Korea's main ally in the region, has warned North Korea it would cut back severely needed food assistance if it carried out a test. Each year China donates approximately half of the food North Korea lacks to feed its people and half of all oil the country consumes.


Suspicions were aroused when the U.S. Geological Survey said it had detected a magnitude 4.9 earthquake Tuesday in North Korea.


The Comprehensive Test Ban Treaty Organization told ABC News, "We confirm that a suspicious seismic event has taken place in North Korea."


"The event shows clear explosion-like characteristics and its location is roughly congruent with the 2006 and 2009 DPRK nuclear tests," said Tibor Toth, executive secretary of the organization.


"If confirmed as a nuclear test, this act would constitute a clear threat to international peace and security, and challenges efforts made to strengthen global nuclear disarmament and non-proliferation," Toth said in a statement on the organization's web site.


Kim Min-seok, a South Korean Defense Ministry spokesman, told reporters that North Korea informed United States and China that it intended to carry out another nuclear test, according to the AP. But U.S. officials did not respond to calls from ABC News Monday night.


The seismic force measured 6 to 7 kilotons, according to South Korea.


"Now that's an absolutely huge explosion by conventional terms. It's a smallish, but not tiny explosion by nuclear terms. It's about two-thirds the size of the bomb that the U.S. dropped on Hiroshima," James Acton, a senior associate at the Carnegie Endowment for International Peace, told ABC News.


North Korea threatened in January to carry out a "higher-level" test following the successful Dec. 12 launch of a long range rocket. At the time, North Korea's leader Kim Jong-Un said his country's weapons tests were specifically targeting the United States.






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Can the internet revive US democracy?



Jim Giles, consultant



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Tech-savvy campaigns get mixed results, as the Arab Spring shows (Image: William Dupuy/Picturetank)



Gavin Newsom's Citizenville shows that technology can empower people, but the book fails to explore deep-rooted problems within the democratic process



THERE'S a lot of crime in Oakland, California. But until a few years ago, citizens had little way of assessing the scale of the problem. Then Michal Migurski hurt his back. It was Christmas 2006 and Migurski, a computer programmer, was stuck at home in Oakland, looking for ways to use his time until his back healed. He knew about the area's crime problem and decided to create an online map showing where and when crimes had been committed - something local government had failed to do.



Migurski's crimespotting.org website gets enthusiastic coverage in Gavin Newsom's Citizenville, a homage to technology's ability to empower people and reform government. If committed and skilled citizens like Migurski can access official data, for example, they can create services that governments don't have time for or aren't well equipped to provide. The internet has already disrupted a swathe of industries, from journalism to telecommunications. Citizenville is packed with examples that show that it is government's turn.





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For the book, Newsom - California's lieutenant governor - talked to a host of Silicon Valley luminaries, from Google founder Sergey Brin to Tim O'Reilly, tech publisher and one of the most high-profile advocates of the idea that technology can transform government. The result is a 239-page tribute to what the valley does best: suggest radical and scalable ways to do things better.



Unfortunately, Newsom's unfettered enthusiasm for the power of the internet and smartphones to transform social and governmental problems makes for a shallow read. Take his analysis of FarmVille, the incredibly successful Facebook game in which players run virtual farms. Why couldn't a similar game be used to help govern a real city, he asks? It's an intriguing idea, based in part on the argument put forward by Jane McGonigal, a game designer, that gaming can be used to solve real-world problems.



But doesn't FarmVille's appeal have much to do with its lack of real-life responsibility? Newsom only touches on this before rushing off to his next tech-inspired solution.



It's a frustrating approach because Newsom was mayor of San Francisco between 2003 and 2010, and rolled out some bold tech-based reforms during his tenure, so he is well placed to discuss the benefits and difficulties of applying technology to governance.



Some of the most interesting parts of Citizenville address ideas that did not work, like radical transparency. After becoming mayor, Newsom decided to post his diary on the web, until his chief of staff pointed out that fundraising meetings would be visible. Newsom relented, accepting that voters don't like to see politicians asking for money.



It's a great example of how technology is just part of the reform equation. To truly empower, technology will have to deal with many entrenched problems, ranging from the shameless distortions that most elected officials spout to the huge number of alienated people who don't register to vote. Any proper assessment of technology's power to change needs to do more than consider the solutions it offers. The impoverished democratic process in the US will not improve until the causes of this situation are part of the discussion.



Broader initiatives exist, of course. Political scientists who study how misinformation spreads have teamed up with technologists to create systems for reining in erroneous memes, like the claim that Barack Obama is not a US citizen. Public health experts are studying not just the internet's ability to communicate health information but also the extent to which that information changes behaviour. It is this kind of thinking, which accepts that technology is only part of the solution, that is missing from Citizenville. I was left wishing that Newsom had focused on just a few of the issues he writes about, and had taken his research beyond the confines of Silicon Valley.



This article appeared in print under the headline "There is no app for political reform"



Book information:
Citizenville: How to take the town square digital and reinvent government by Gavin Newsom and Lisa Dickey
Penguin
$25.95

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Football: Bookmakers pay out early on United winning title






LONDON: Rival betting firms Betfred and Paddy Power have seen enough of the Premier League race to take the gamble of paying out early on Manchester United winning the title, despite the fact there are still 12 matches to play.

Betfred boss Fred Done has risked facing the wrath of his fellow United supporters, paying out early again despite twice having his fingers burnt by making such a move before, including when Alex Ferguson's side were overhauled by neighbours City in the dying minutes of last season.

That decision cost the Salford-born bookmaker over £1 million (1.173 million euros) and led some fans to accuse him of jinxing the Old Trafford outfit, having also paid the price for a similar move when Arsenal clawed back a huge deficit in 1998.

However, with United again a dozen points ahead of their nearest rivals following a 2-0 defeat of Everton, Done has seen enough to declare them champions for a record 20th time.

"After it all went wrong last year, my missus made me promise to never do it again, but with United 12 points clear with just 12 games left the title race is over - so my punters can collect their dough on United." explained Done.

Irish bookmakers Paddy Power, had already stolen a march on their competitors by paying out on United to finish top of the table, even before they had claimed their victory on Sunday.

A spokesman for the firm declared: "The fat lady might not be singing yet but she's definitely getting warmed up.

"We can't see United letting their lead slip and, with Real Madrid to come in midweek (Champions League first-leg), we thought we'd take some of the pressure off Fergie (Ferguson) and give punters an early payday."

-AFP/ac



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iPhone 5 rated fifth in user satisfaction in new study



The iPhone 5 trailed four Android phones for user satisfaction, according to a new report out today.


Conducted by mobile research firm OnDevice Research, the poll asked 320,000 smartphone and
tablet users in six countries how satisfied they were with their devices. Among the 93,825 people surveyed in the U.S., Motorola's Atrix HD came out on top, followed by Motorola's
Droid Razr M, HTC's Rezound 4G, and Samsung's Galaxy Note 2, leaving the
iPhone 5 in fifth place.

"Although Apple created one of the most revolutionary devices of the past decade, other manufactures have caught up, with some Android powered devices now commanding higher levels of user satisfaction," On Device Research marketing manager Sarah Quinn said in a statement.

Apple did fare better among the 52,140 people polled in the U.K., where it took second place behind HTC's One X. Samsung's Galaxy Note 2 was No. 3 for user satisfaction, followed by its Galaxy S3 Mini and the full-size Galaxy S3.

Among the rankings for overall mobile device satisfaction in the U.S., Apple took the top spot. Google was ranked second, followed by Motorola, HTC, Nokia, and Sony Ericsson. And for some unknown reason, Samsung was ranked at the very bottom.

4G also played a role in user satisfaction. The top five devices in the U.S. all support 4G, and people with a 4G subscription were slightly more satisfied than were those stuck at 3G.

The survey reached mobile users in the U.S., the U.K., France, Germany, Japan, and Indonesia.

Some of the findings seem a bit odd, especially since OnDevice Research didn't reveal all of the devices included in the survey. Google was ranked second in mobile device satisfaction, but Google itself is not an actual device maker. And why Samsung was at the bottom of the satisfaction list is a mystery.

CNET has contacted OnDevice Research for feedback on its survey results and will update the story if we receive any further information.

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Year of the Snake: The Serpent Behind the Horoscope


On February 10, people all around the world will ring in the Lunar New Year with paper lanterns and firecrackers. At the heart of it all sits the snake, a slithery reptile feared for its sharp fangs and revered for its undeniable charm. (Watch videos of some of the world's deadliest snakes.)

Those born in the Year of the Snake are said to be intelligent and quick thinking, but they can also be dishonest and prone to show off. Though based on Chinese astrology, some of these traits are similar to characteristics of the actual serpent.

Snakes are known to be great at outsmarting their predators and prey. Their colorful, patterned skin makes them some of the best tricksters in the animal kingdom. And despite a bad rap as frightening creatures, snakes never fail to fascinate scientists, explorers, and zoo-goers. (See pictures of snakes.)

With more than 3,400 recognized species, snakes exhibit incredible diversity in everything from behavior and habitats to skin colors and patterns.

"As a vertebrate lacking in limbs, all snakes look largely like other snakes, yet they succeed in tremendous diversity in multiple directions," said Andrew Campbell, herpetology collections manager at the University of Kansas Biodiversity Institute.

To usher in the Year of the Snake, Campbell and herpetologist Dennis Ferraro at University of Nebraska-Lincoln weigh in on some of the snake's qualities that the Chinese zodiac predicts people born this year will have.

Horoscope: Snakes have an innately elegant personality but can also be ostentatious at times.

In Nature: Snakes come in all different colors, patterns, and textures, making them some of nature's most visually stunning creatures.

According to Campbell, the utility of their coloring falls into two main categories: to use as camouflage and to warn predators to stay away.

Among the most beautiful are the emerald tree boa (Corallus caninus)—whose vibrant green body is decorated with white stripes resembling lightning bolts—and the Brazilian rainbow boa (Epicrates cenchria), characterized by its iridescent skin and the large black rings down its back.

For some snakes, the diversity in color occurs within the same species, which is why Ferraro tells his student not to identify snakes by colors. For example, the polymorphic bush viper (Atheris squamigera), many of which are green, also come in shades of yellow, orange, red, and blue, as captured in photographer Guido Mocafico's "Serpent Still Life" photo series.

Horoscope: The snake is known to be the master seducer of the Chinese zodiac.

In Nature: Female garter snakes (Thamnophis) have all the luck with the gentlemen.

When a female garter snake is ready to mate, she announces it by producing chemicals called pheromones. Males, upon encountering the scent, immediately come crawling out and gather around the female in a large, wriggling "mating ball."

The competition intensifies when a male passing by the ball tries to fool the others by producing a scent that mimics that of the female, said Ferraro.

As soon as his rivals are led off in the wrong direction, the trickster slides right in. In areas with smaller populations of garter snakes, each ball consists of about 12 males and one female.

But in places like Manitoba, Canada, where garter snakes travel to certain areas to mate after coming out of hibernation, a mating ball can have thousands of males and only a hundred females.

Horoscope: Though snakes don't often tell lies, they will use deception when they feel it's necessary and they think they can get away with it.

In Nature: When it comes to using trickery to catch dinner, or to hide from predators, snakes are no amateurs.

Their sneaky techniques range from tricking fish to swim right into their mouths, to playing dead when threatened, to using their wormlike tails to lure in prey.

The most cunning of them all is the two-headed snake. To protect against a sneak attack from behind, the two-headed snake's tail looks just like its head. While the business end looks for food, the snake coils up its body and rests its tail on top to look like it is on guard.

The tail can even mimic the behavior of a retreating snake to trick predators into thinking they're going face-to-face with their opponent.

Horoscope: When snakes get down to work, they are organized and highly efficient, and they work quickly and quietly.

In Nature: While snakes are often perceived as lazy, Campbell said people are mistaken. "What we perceive as shy, lazy, or inactive is really efficiency," he said.

"On average, they are bigger than other lizards and can build a lot of body mass. They do that by being efficient in feeding and traveling." In other words, snakes don't move very much because they don't have to.

When it comes to food, snakes catch prey that are significantly larger than them so they can eat less frequently. This reduces the time they spend hunting and thus makes them less vulnerable to falling victim to a predator themselves.

For Campbell, the most impressive hunter is the eastern diamondback rattlesnake (Crotalus Adamanteus), which is able to hunt and kill its prey very quickly using venom, so it doesn't have to travel far. "Because they don't have to do that, they can become relatively large and heavy, being able to build up body mass and not having to spend that energy hunting."

Horoscope: Snakes are charming, with excellent communication skills.

In Nturea: For snakes, their visual and auditory senses don't mean much when it comes to communicating with each other.

Instead, they use their sense of smell and the chemicals produced by their musk glands. Unlike mammals, a snake picks up scent through the forks of its tongue.

When the snake retracts its tongue, it inserts the forks into grooves in an olfactory organ located at the roof of its mouth. Depending on which fork picks up a stronger scent, the snake knows in which direction to go when looking for prey or a mate.

It's when snakes are threatened that they use sight and sound, said Ferraro. Rattlesnakes, for example, shake their tails, making a loud rattling noise to ward off predators.


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Vatican Says Pope Benedict Will Resign Feb. 28













Pope Benedict XVI announced today that he will resign Feb. 28, saying his role requires "both strength of mind and body."


The pope's decision makes him the first pontiff to resign in nearly 600 years. A conclave to elect a new pope will take place before the end of March. The 85-year-old pope announced the decision to resign in Latin during a meeting of Vatican cardinals.


VIDEO: Pope Benedict to Resign, Vatican Says


"After having repeatedly examined my conscience before God, I have come to the certainty that my strengths due to an advanced age are no longer suited to an adequate exercise of the Petrine ministry," he said. "I am well aware that this ministry, due to its essential spiritual nature, must be carried out not only by words and deeds but no less with prayer and suffering."


Pope Benedict XVI was the oldest pope to be elected at age 78 on April 19, 2005. He was the first German pope since the 11th century and his reign will rank as one of the shortest in history at seven years, 10 months and three days.


RELATED: Pope Benedict XVI Resigns: The Statement


The last pope to resign was Pope Gregory XII, who stepped down in 1415.










Pope Benedict XVI Resignation: Who Will Be Next? Watch Video







Vatican officials said they've noticed that he had been getting weaker, while Benedict said he is aware of the significance of his decision and made it freely.


Benedict's brother, the Rev. Georg Ratzinger, had shared his concerns about the pope's health in September 2011, telling Germany's Bunte magazine that he should resign if health issues made the work impossible. More recently, Ratzinger has apparently cited his brother's difficulty in walking and his age, saying that Benedict had been advised by his doctor to cease transatlantic trips and that he had been considering stepping down for months, according to the German DPA news agency.


Benedict has been a less charismatic leader than his predecessor, John Paul II, but tending to the world's roughly 1 billion Catholics still requires stamina Benedict seems to believe he now lacks.



PHOTOS: Pope Benedict XVI Through the Years


"Obviously, it's a great surprise for the whole church, for everyone in the Vatican and I think for the whole Catholic world," the Rev. John Wauck, a U.S. priest of the Opus Dei, told "Good Morning America" today. "But, at the same time, it's not completely surprising given what the pope had already written about the possibility of resigning.


"It's clear in terms of his mental capacity he's in excellent shape, he's very sharp, and so when he says he's making this official with whole freedom, it's clear that that's the case, that makes one believe that this is an act taken out of a sense of responsibility and love for the church."


It is a road that leads back to the 1930s.


Ratzinger started seminary studies in 1939 at the age of 12. In his memoirs, he wrote of being enrolled in Hitler's Nazi youth movement against his will when he was 14 in 1941, when membership was compulsory. In 1943, he was drafted into a Nazi anti-aircraft unit in Munich. He says he was soon let out because he was a priest in training.


He returned home only to find an army draft notice waiting for him in the fall of 1944.


As World War II came to an end, the 18-year-old Ratzinger deserted the army. In May 1945, U.S. troops arrived in his town and he was sent to a prisoner-of-war camp.






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