False memories prime immune system for future attacks

IN A police line-up, a falsely remembered face is a big problem. But for the body's police force – the immune system – false memories could be a crucial weapon.

When a new bacterium or virus invades the body, the immune system mounts an attack by sending in white blood cells called T-cells that are tailored to the molecular structure of that invader. Defeating the infection can take several weeks. However, once victorious, some T-cells stick around, turning into memory cells that remember the invader, reducing the time taken to kill it the next time it turns up.

Conventional thinking has it that memory cells for a particular microbe only form in response to an infection. "The dogma is that you need to be exposed," says Mark Davis of Stanford University in California, but now he and his colleagues have shown that this is not always the case.

The team took 26 samples from the Stanford Blood Center. All 26 people had been screened for diseases and had never been infected with HIV, herpes simplex virus or cytomegalovirus. Despite this, Davis's team found that all the samples contained T-cells tailored to these viruses, and an average of 50 per cent of these cells were memory cells.

The idea that T-cells don't need to be exposed to the pathogen "is paradigm shifting," says Philip Ashton-Rickardt of Imperial College London, who was not involved in the study. "Not only do they have capacity to remember, they seem to have seen a virus when they haven't."

So how are these false memories created? To a T-cell, each virus is "just a collection of peptides", says Davis. And so different microbes could have structures that are similar enough to confuse the T-cells.

To test this idea, the researchers vaccinated two people with an H1N1 strain of influenza and found that this also stimulated the T-cells to react to two bacteria with a similar peptide structure. Exposing the samples from the blood bank to peptide sequences from certain gut and soil bacteria and a species of ocean algae resulted in an immune response to HIV (Immunology, doi.org/kgg).

The finding could explain why vaccinating children against measles seems to improve mortality rates from other diseases. It also raises the possibility of creating a database of cross-reactive microbes to find new vaccination strategies. "We need to start exploring case by case," says Davis.

"You could find innocuous pathogens that are good at vaccinating against nasty ones," says Ashton-Rickardt. The idea of cross-reactivity is as old as immunology, he says. But he is excited about the potential for finding unexpected correlations. "Who could have predicted that HIV was related to an ocean algae?" he says. "No one's going to make that up!"

This article appeared in print under the headline "False memories prime our defences"

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PM Lee urges couples to have confidence in S'pore's future

SINGAPORE: Prime Minister Lee Hsien Loong said it is important for couples to have confidence in Singapore's future and ultimately want Singapore to be the best place to settle down and raise children.

He was speaking at the Lunar New Year dinner at his Teck Ghee ward on Saturday evening.

He said: "Here, your children will get good education, will have good opportunities, that here we can build a home together. A home where we feel Singaporean, a home where we can have opportunities, a home where we can help look after one another, and make tomorrow better than today."

The government recently announced a Marriage and Parenthood package that aims to help Singaporeans settle down and raise children.

However, Mr Lee noted that parents are worried about childcare arrangements.

He said: "It's not easy because a lot of couples now, both parents are working and cannot always rely on grandparents to look after their kids because the grandparents may be older, may no longer be in good health, may not have the strength to take care of the grandchildren anymore. So, we need infant care and childcare facilities."

Mr Lee said building more childcare facilities will take time. He also said the centres can be set up quickly, but good teachers take time to train.

He added what is most important is to make it easier for parents to spend time with their children.

Mr Lee said: "So, we have paternity leave, we have shared parental leave, and these are big steps forward. We are also promoting good work-life balance, flexible work arrangements, and I think if we can do that, then that's the best hong bao which parents can give their children - our love and attention. I hope these measures will encourage couples to marry and to have more children."

Mr Lee said he is confident that Singapore can be transformed into a better place and next generation will do its part to improve it.

- CNA/xq

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How Apple got serious about style

Humble beginnings -- an early conceptual modular Apple tablet from 1982.

(Credit:
Harmut Esslinger, Frog Design)

When Frog Design founder Hartmut Esslinger met Steve Jobs in 1982, it sparked a chain of events that monumentally changed Apple's design philosophy forever. It wasn't just a change in how future products would look -- Esslinger ushered in a change of mindset and a unified design language across products. Esslinger's new book, "Design Forward: Creative Strategies for Sustainable Change," available today in the U.S., delivers some fascinating insights into those crucial early years at Apple.

The dialect that emerged from that period, known as the Snow White design language, influenced dozens of Apple devices starting with the Apple IIc in 1984 and lasting until the Macintosh IIfx in 1990.

Our gallery below starts off with a range of computers that earned Frog Design a hefty annual contract and a role as a leader in Apple's product design process. The two companies didn't just create computers, however; they went beyond and created a mock
tablet, computer phone, flat-screen devices, and more.

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Why the Dog Show Winner Looks Like a Monkey

Standing less than a foot tall and easily cradled in one of trainer Ernesto Lara's arms, Banana Joe made big news for a small dog when he became the first affenpinscher to win the Westminster Kennel Club dog show on Tuesday.

His short stature and flattened face might not make Banana Joe look like a typical winner: The name "affenpinscher" is German for "monkey terrier," and its mug is definitely simian in appearance. Now this lesser known breed is basking in the spotlight, monkey face and all. (Read "How to Build a Dog" in National Geographic magazine.)

Why the Flat Face?

People like dogs whose faces kind of look like people, with a squished-in nose and forward-facing eyes: Pekinese, bullmastiffs, and affenpinschers, to name a few. "It's mimicking the way humans appear," said Jeffrey Schoenebeck, a research fellow at the National Institutes of Health who has analyzed the development of shortened canine snouts. Several centuries ago, breeders probably sought out parents with a flat face. (Genetics note: Gene BMP3 likely contributes to a flat face in toy breeds.)

And so Banana Joe's mug reflects centuries of genetic manipulation. There's no advantage for the dog, Schoenebeck notes, except that humans would crave it more as a companion. (Related: Gallery of Dog Pictures.)

What About That Tongue?

Banana Joe sticks out his little pink tongue a lot. Maybe more than your run-of-the-mill canine. The reason may be the flat face. "There's probably less room in their mouth" for the tongue, said Schoenebeck. "It's hanging out."

Why so Small?

"The Affenpinscher comes from a terrier background," explained NIH senior staff scientist Heidi Parker, and like all terriers, it was bred to chase. The early affenpinschers' specialty was hunting down rats and other vermin for its owners. Breeding for a small size came later, as ladies started bringing affenpinschers into the home as lap dogs-and to keep away vermin that might otherwise hide in corners or under long skirts. Today's affenpinschers are in the 6-to-13 pound (3-to-6 kilogram) range.

But the dog's size hasn't given it an inferiority complex. "Most of these little guys do not realize they're as small as they are," Parker says. Toy dogs have been known to chase birds and other animals that rival them in size.

What Comes After Westminster?

Dog lovers may crave an affenpinscher. And that could cause problems if breeders try to produce more pups.

"You'll see some breeds go through sudden explosions, where they'll go from small numbers to really large numbers," says Parker. "Usually that means an increase in genetic diseases." There aren't a lot of potential parents for a purebred litter, so the odds of inbreeding, and its related diseases, go up.

And What About Banana Joe?

Now that he's made us aware of his breed, Banana Joe will retire from competition and live with his Dutch owner, free to fulfill his heritage as a lap dog.

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Budget Cut Warnings Harsher Than Reality?

Get ready for two weeks of intensifying warnings about how crucial, popular government services are about to wither — including many threats that could eventually come true.

President Barack Obama and congressional Republicans made no progress last week in heading off $85 billion in budget-wide cuts that automatically start taking effect March 1. Lacking a bipartisan deal to avoid them and hoping to heap blame and pressure on GOP lawmakers, the administration is offering vivid details about the cuts' consequences: trimmed defense contracts, less secure U.S. embassies, furloughed air traffic controllers.

Past administrations have seldom hesitated to spotlight how budget standoffs would wilt programs the public values.

When a budget fight between President Bill Clinton and congressional Republicans led to two government shutdowns, in 1995 and 1996, some threats came true, like padlocked national parks.

Others did not.

Clinton warned that Medicare recipients might lose medical treatment, feeding programs for the low-income elderly could end and treatment at veterans hospitals could be curtailed. All continued, thanks to contractors working for IOUs, local governments and charities stepping in and the budget impasse ending before serious damage occurred.

Andrew Harrer/Bloomberg/Getty Imag

This time, at stake is not a federal shutdown but a so-called sequester. Between March 1 and Sept. 30 — the remainder of the government's budget year — it would mean reductions of 13 percent for defense programs and 9 percent for other programs, according to the White House budget office.

The cuts, plus nearly $1 trillion more over the coming decade, were concocted two years ago. Administration and congressional bargainers purposely made them so painful that everyone would be forced to reach a grand deficit-cutting compromise to avoid them.

Hasn't happened.

A look at the sequester and the chilling impact the administration says it would have, based on letters and testimony to Congress:

—A key reminder: Social Security, Medicare and veterans' benefits, Medicaid and a host of other benefit programs are exempted. The cuts take effect over a seven-month period; they don't all crash ashore on March 1. And if a bipartisan deal to ease them is ever reached, lawmakers could restore some or all of the money retroactively.

—On the other hand: Left in effect, these cuts are real even though their program-by-program impact is unclear. The law limits the administration's flexibility to protect favored initiatives, but the White House has told agencies to avoid cuts presenting "risks to life, safety or health" and to minimize harm to crucial services.

—Defense: Troops at war would be protected, but there'd be fewer Air Force flying hours, less training for some Army units and cuts in naval forces. A $3 billion cut in the military's Tricare health care system could diminish elective care for military families and retirees. And, in a warning to the private defense industry, the Pentagon said it would be "restructuring contracts to reduce their scope and cost."

—Health: The National Institutes of Health would lose $1.6 billion, trimming cancer research and drying up funds for hundreds of other research projects. Health departments would give 424,000 fewer tests for the AIDS virus. More than 373,000 people may not receive mental health services.

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Brecht's Galileo is a play for our times

Tiffany O'Callaghan, Opinion editor

Ian McDiarmid as Galileo (left) and James Tucker as the Bursar (Image: Ellie Kurtz)

It has been more than 400 years since Galileo Galilei pointed his telescope toward the night sky and observed the movement of the moons around Jupiter, providing proof that all things do not revolve around the Earth - and drawing the ire of the Catholic church.

And it has been nearly 80 years since playwright Bertolt Brecht wrote the first version of A Life of Galileo while living in Denmark after fleeing Germany when Hitler took power.

Yet the latest retelling of this famous tale by the Royal Shakespeare Company underscores the emphatically contemporary nature of the struggle between static world views and dynamic knowledge.

This is reinforced by using the familiar, modern clothing of tweedy dishevelment among Galileo and his colleagues and pupils, and sets featuring the lab-staple whiteboard and a large blue backdrop that resembles a wall of solar panels.

But of course this is not simply an old story with modern accoutrements and gimmicky staging. Portrayed by Ian McDiarmid, Galileo’s compulsive curiosity, his sheer joy when his pupil grasps a new concept for the first time, and his bewildered frustration when adversaries refuse to observe the evidence literally in front of them feel both timely and timeless. “All I ask is for them to believe their eyes!” exclaims poor Galileo.

In a moment when 46 per cent of US citizens believe the Earth is less than 10,000 years old and four US states are weighing up bills that would challenge the teaching of evolution, the tension remains strong between theologies that carve out a creation story for humans and the evidence that we are the serendipitous result of millions of years of evolution.

There are strong reminders of these tensions in the play, for example, when a cleric bullies Galileo to keep his heliocentric ideas to himself, crystallising the church’s terror at the implications of his ideas: “Is no one watching us?" asks the cleric. "Has no one imagined a part for us to play other than this one?”

Galileo is cowed into compromise. His new ideas may be used to help seafarers better navigate by the stars, but not to upend the understanding of the order of things. They may answer practical questions, but not existential ones. “We may research, but we may not draw conclusions.”

He accepts the new conditions in word only. His experiments continue, and when given the slimmest opening his feverish curiosity breaks out into the light of day. When he learns that his friend and science enthusiast Cardinal Barberini may ascend to the papacy, he lauds the arrival of an era of reason. Too soon, of course.

In the second act, we meet the new pope in his undergarments. As he debates the use of torture and threats to force Galileo to renounce the Copernican ideas laid out in his Dialogue Concerning the Two Chief World Systems, Barberini dons layer upon layer of vestments. Crimson robes, a glittering great cape, and finally the mitre: when he is cloaked in the power of his office, Barberini assents to the threat of torture.

The scene parallels the opening scene of the play, in which Galileo, also in only his undergarments, is bathing and getting ready for the day. The contrast is evident: in the flesh, they are both ageing men. But their power to spread ideas is proportional to the grandeur of their garments. When Galileo is threatened and ultimately abjures his earlier assertions, he returns beaten and bare-legged in a crumpled white gown.

The legacy of Galileo’s recantation is left open. Brecht rewrote aspects of the play following the bombings of Hiroshima and Nagasaki in 1945, when he was living in the US. “Overnight the biography of the founder of the new system of physics read differently,” he wrote in an introduction to the new version. “The infernal effect of the great bomb placed the conflict between Galileo and the authorities of his day in a new sharper light.”

Brecht never saw the stage production of his later version in New York, as he left the country after being questioned by the House Committee on Un-American Activities.

By the end of the play, Galileo is wary of science shaped by interests more nefarious than the quest for truth. He sees a danger in scientists being reduced to little more than “inventing pygmies” for sale to the highest bidder, their ideas open to be used for cruel ends. Galileo’s public recantation and private pursuit of truth and Brecht’s ambivalence about the responsibility of scientists to shape the use of their research for the benefit of humankind are not necessarily two sides of the same coin, it seems.

But it isn’t clear that in publicly defying the church Galileo would have reshaped the way that scientific knowledge is applied. And in real life, as in the play, in sneaking his final, influential publication Discourse and Mathematical Demonstrations About Two New Sciences out under the noses of the church which held him under house arrest for the final years of his life, Galileo seems vindicated in his decision to live to think another day.

As New Yorker critic Adam Gopnik recently put it, “the best reason we have to believe in the moons of Jupiter is that no one has to be prepared to die for them in order for them to be real”.

It may be an excruciatingly slow process, but the truth has a way of emerging into the light eventually. It was just two decades ago - and 350 years after Galileo’s death - that the Catholic church finally admitted that it had been wrong to condemn him.

A Life of Galileo is on at the Swan Theatre, Stratford-upon-Avon, UK, until 30 March.

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TCM slowly gaining popularity in Middle East

EAST JERUSALEM: Traditional Chinese Medicine (TCM) is slowly gaining popularity in North Africa and the Middle East.

But advocates still face an uphill task of convincing governments to accept it as an alternative form of medical treatment.

Dr Adi Fromm's hospital ward is well known throughout Israel.

Patients disheartened with Western painkillers come here looking for relief.

An example is a man who suffered from pain in his legs for years.

Nothing helped until Dr Adi introduced him to Chinese "magic needles" or acupuncture.

Dr Fromm, who is the head of the TCM Association Israel, said: "The first challenge is to make the Western medicine profession understand that TCM is a valid tool in what I call the 'health basket' that we can give to people...we are still fighting for our legitimacy (among practitioners of) Western medicine."

TCM dates back more than 5,000 years, but it is now slowly being embraced as a holistic alternative to Western medicine in many countries across the Middle East and North Africa.

In Israel, it was only formally recognised in the early 1990s.

Despite its popularity, it is still not widely used by the mainstream healthcare system.

In places like Tunisia in North Africa, there is even less awareness.

Practitioners here face an uphill battle in seeking acceptance of TCM.

Twenty years ago, the first Chinese doctors visited these shores. Since then, the number of acupuncturists has been steadily growing.

Dr Mohammed Juaied, a TCM doctor in Tunis, said: "A lot of people are asking for this type of medicine and we are hoping that more doctors here will be trained in this type of treatment."

Suspicion and lack of knowledge mean it is hardly practised at all.

Dr Abbas Elias Yousef Zaro, an alternative medicine practitioner, is trying to change all this.

From his modest clinics in East Jerusalem and Ramallah, he brings hope to dozens of Palestinian patients frustrated with modern medicine.

He said: "When I finished my studies and came back to Palestine, I opened a clinic in Ramallah. For the first five years, people did not accept it very much but things have changed since then. Still, the government has no plans to bring alternative medicine to the hospitals."

This echoes Dr Layla Abu Ahmmad Esmaeel's experience across the border.

Although her clinic sees a steady stream of well-to-do Egyptians, she is lobbying her government for greater recognition of this ancient science.

Dr Layla, from the Acupuncture Clinic at the National Research Centre, said: "We are working hard with the Egyptian government to approve this kind of medicine because the Minister of Health (has) not (approved) TCM. A lot of doctors are practising this kind of medicine without...enough knowledge."

Elsewhere in the world, TCM has been more readily accepted.

There are laws in countries as far afield as Australia and South Africa that regulate and protect it.

This is an encouraging sign for its advocates in the Middle East.

TCM has come a long way in overcoming the misunderstandings and criticisms of the Western world. In recent years, its popularity, especially in the Middle East, has grown, allowing it to be used more frequently in treating the pains and stresses of the region.

- CNA/ms

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Xbox 360 again the most popular console among U.S. gamers

Microsoft has extended its streak of console sales leadership into its third year.

Research firm NPD yesterday released its game-market sales for January. Microsoft led U.S. console sales for the 25th-consecutive month, tallying 281,000 units sold. At that sales level, Microsoft was able to grab 44 percent console market share. All told, consumers spent $338 million on
Xbox 360 hardware, software, and accessories during the period.

Despite the Xbox 360's success, overall hardware sales were down 17 percent compared to January 2011, reaching $205 million during the period. Software sales hit $373.1 million, and total industry sales across hardware, software, and accessories, was $834.7 million.

Compared to January 2012, those figures appear to be up year-over-year. However, NPD's data is based on a system that covers 364 of the 365 days in a year. Therefore, every five or six years, the company must add a so-called "Leap Week" to ensure its data is accurate and accounts for all days. This January, NPD used its Leap Week, meaning the period included an extra week compared to January 2012.

It's not clear by how much Microsoft was able to top its competitors in the console market. Both Sony and Nintendo have so far remained tight-lipped on actual unit sales during January, and NPD does not publicly release hardware unit sales.

On the software side, Call of Duty: Black Ops II was once again the leader, followed by Far Cry 3 and Just Dance 4. NBA 2K 13 and Madden NFL 13 rounded out the top five.

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Why We Walk … and Run … And Walk Again to Get Where We're Going

You have to get to a bus stop to catch the once-an-hour express ... or to a restaurant to meet a friend ... or to a doctor's office. You've got maybe a half a mile to cover and you're worried you'll be late. You run, then you stop and walk, then run some more.

But wait. Wouldn't it be better to run the whole way?

Not necessarily.

A new study by an assistant professor of mechanical engineering at Ohio State University tests the theory that people subconsciously mix walking and running so they get where they need to. The idea is that "people move in a manner that minimizes energy consumption," said the professor, Manoj Srinivasan.

Srinivasan asked 36 subjects to cover 400 feet (122 meters), a bit more than the length of a football field. He gave them a time to arrive at the finish line and a stopwatch. If the deadline was supertight, they ran. If they had two minutes, they walked. And if the deadline was neither too short nor too far off, they toggled between walking and running.

The takeaway: Humans successfully make the walk-run adjustment as they go along, based on their sense of how far they have to go. "It's not like they decide beforehand," Srinivasan said. (Get tips, gear recommendations, and more in our Running Guide.)

The Best Technique for "the Twilight Zone"

"The mixture of walking and running is good when you have an intermediate amount of time," he explained. "I like to call it 'the Twilight Zone,' where you have neither infinite time nor do you have to be there now."

That ability to shift modes served ancient humans well. "It's basically an evolutionary argument," Srinivasan said. A prehistoric human seeking food would want to move in a way that conserves some energy so that if food is hard to find, the hunter won't run out of gas—and will still be able to rev it up to escape predators.

The study, published on January 30 in the Journal of the Royal Society Interface, doesn't answer that question of how we make such adjustments.

Runners: Take a Break if You Need It

The mix of walking and running is also something that nonelite marathoners are familiar with. Covering 26.2 miles might take less of a toll if the runner stops running from time to time, walks a bit, then resumes a jogging pace. "You use less energy overall and also give yourself a bit of a break," Srinivasan noted. (Watch: An elite marathoner on her passion for running.)

One take-home lesson is: Runners, don't push it all the time. A walk-run mix will minimize the energy you expend.

Lesson two: If you're a parent walking with your kid, and the kid lags behind, then runs to catch up, then lags again, the child isn't necessarily trying to annoy you. Rather, the child is perhaps exhibiting an innate ability to do the walk-run transition.

Potential lesson three: The knowledge that humans naturally move in a manner that minimizes energy consumption might be helpful in designing artificial limbs that feel more natural and will help the user reduce energy consumption.

The big question for Manoj Srinivasan: Now that he has his walk-run theory, does he consciously switch between running and walking when he's trying to get somewhere? "I must admit, no," he said. "When I want to get somewhere, I just let the body do its thing." But if he's in a rush, he'll make a mad dash.

"Talk to you tomorrow," he signed off in an email to National Geographic News. "Running to get to teaching now!"

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Falling Meteor Causes Blast, Injures Hundreds

A massive meteor shower slammed into Earth near the Russian city of Chelyabinsk, located about 1,000 miles east of Moscow in the Ural Mountains.

Dashboard cameras captured a blinding flash of light streaking across the sky. Moments later, the fragments smashed into the ground. The impact, and the sonic boom of the meteor entering the atmosphere, shattered windows around the city and knocked over a wall at a zinc factory.

Witnesses said they thought a war had broken out.

"I saw a body moving in the skies. In a moment there came a flash - we first thought it was fireworks but a moment later we saw a trace as if from the rocket followed by an explosion in a couple of minutes. The window broke ... tea, bread, water - everything fell on the floor," one restaurant waiter in Chelyabinsk said.

Officials told the Russian news agency Interfax that more than 500 people were injured, most by broken glass. Of the 12 people hospitalized, at least three of them were in serious condition.

One scientist told Russian television the meteor was a big one, weighing perhaps tens of tons, but stressed that it was not related to the asteroid that is expected to buzz close to Earth later today.

Regional officials said the one large fragment fell in a lake, but debris had been reported in three parts of Russia and in Kazakhstan.

Schools in the region closed for the day after most of the windows were blown out, citing freezing temperatures, which were below zero degrees Fahrenheit during the day.

Debris from the meteor was found in three sites around the country, but emergency services say ground zero was Chebarkul Lake, just west of Chelyabinsk.

The meteor knocked out cell phone networks, but electricity and water supplies were not affected. Rosatom said all its nuclear power facilities were functioning normally.

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